Single molecule mass measurements and mass spectrometry
نویسندگان
چکیده
منابع مشابه
Single-molecule mass spectrometry.
In single-molecule mass spectrometry, the mass of each ion is measured individually; making it suitable for the analysis of very large, heterogeneous objects that cannot be analyzed by conventional means. A range of single-molecule mass spectrometry techniques has been developed, including time-of-flight with cryogenic detectors, a quadrupole ion trap with optical detection, single-molecule Fou...
متن کاملTowards single-molecule nanomechanical mass spectrometry
Mass spectrometry provides rapid and quantitative identification of protein species with relatively low sample consumption. The trend towards biological analysis at increasingly smaller scales, ultimately down to the volume of an individual cell, continues, and mass spectrometry with a sensitivity of a few to single molecules will be necessary. Nanoelectromechanical systems provide unparalleled...
متن کاملToward single-molecule nanomechanical mass spectrometry
Mass spectrometry provides rapid and quantitative identification of protein species with relatively low sample consumption. The trend towards biological analysis at increasingly smaller scales, ultimately down to the volume of an individual cell, continues, and mass spectrometry with a sensitivity of a few to single molecules will be necessary. Nanoelectromechanical systems provide unparalleled...
متن کاملSingle-molecule mass spectrometry in solution using a solitary nanopore.
We introduce a two-dimensional method for mass spectrometry in solution that is based on the interaction between a nanometer-scale pore and analytes. As an example, poly(ethylene glycol) molecules that enter a single alpha-hemolysin pore cause distinct mass-dependent conductance states with characteristic mean residence times. The conductance-based mass spectrum clearly resolves the repeat unit...
متن کاملEnhanced single molecule mass spectrometry via charged metallic clusters.
Nanopore sensing is a label-free method for characterizing water-soluble molecules. The ability to accurately identify and characterize an analyte depends on the residence time of the molecule within the pore. It is shown here that when a Au25(SG)18 metallic cluster is bound to an α-hemolysin (αHL) nanopore, the mean residence time of polyethylene glycol (PEG) within the pore is increased by ov...
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ژورنال
عنوان ژورنال: Rapid Communications in Mass Spectrometry
سال: 2016
ISSN: 0951-4198,1097-0231
DOI: 10.1002/rcm.7756